Peanut‐induced anaphylaxis in children and adolescents: Data from the European Anaphylaxis Registry

Background Peanut allergy has a rising prevalence in high-income countries, affecting 0.5%-1.4% of children. This study aimed to better understand peanut anaphylaxis in comparison to anaphylaxis to other food triggers in European children and adolescents. Methods Data was sourced from the European Anaphylaxis Registry via an online questionnaire, after in-depth review of food-induced anaphylaxis cases in a tertiary paediatric allergy centre. Results 3514 cases of food anaphylaxis were reported between July 2007 - March 2018, 56% in patients younger than 18 years. Peanut anaphylaxis was recorded in 459 children and adolescents (85% of all peanut anaphylaxis cases). Previous reactions (42% vs. 38%; p = .001), asthma comorbidity (47% vs. 35%; p < .001), relevant cofactors (29% vs. 22%; p = .004) and biphasic reactions (10% vs. 4%; p = .001) were more commonly reported in peanut anaphylaxis. Most cases were labelled as severe anaphylaxis (Ring&Messmer grade III 65% vs. 56% and grade IV 1.1% vs. 0.9%; p = .001). Self-administration of intramuscular adrenaline was low (17% vs. 15%), professional adrenaline administration was higher in non-peanut food anaphylaxis (34% vs. 26%; p = .003). Hospitalization was higher for peanut anaphylaxis (67% vs. 54%; p = .004). Conclusions The European Anaphylaxis Registry data confirmed peanut as one of the major causes of severe, potentially life-threatening allergic reactions in European children, with some characteristic features e.g., presence of asthma comorbidity and increased rate of biphasic reactions. Usage of intramuscular adrenaline as first-line treatment is low and needs to be improved. The Registry, designed as the largest database on anaphylaxis, allows continuous assessment of this condition

The Aeolus Data Innovation and Science Cluster

The Data Innovation and Science Cluster (DISC) is a core element of ESA's data quality strategy for the Aeolus mission, which was launched in August 2018. Aeolus provides for the first-time global observations of vertical profiles of horizontal wind information by using the first Doppler wind lidar in space. The Aeolus DISC is responsible for monitoring and improving the quality of the Aeolus aerosol and wind products, for the upgrade of the operational processors as well as for impact studies and support of data usage. It has been responsible for multiple significant processor upgrades which reduced the systematic error of the Aeolus observations drastically. Only due to the efforts of the Aeolus DISC team members prior to and after launch, the systematic error of the Aeolus wind products could be reduced to a global average below 1 m/s which was an important pre-requisite for making the data available to the public in May 2020 and for its use in operational weather prediction. In 2020, the reprocessing of earlier acquired Aeolus data, another important task of the Aeolus DISC, also started. In this way, also observations from June to December 2019 with significantly better quality could be made available to the public, and more data will follow this and next year. Without the thorough preparations and close collaboration between ESA and the Aeolus DISC over the past decade, many of these achievements would not have been possible

The SCIAMACHY Consolidated Level 0 Dataset

By the end of the ENVISAT mission, SCIAMACHY had executed 52867 orbits. In most of those SCIAMACHY acquired measurement data. SCIAMACHY’s complex measurement schemes are best reflected in the consolidated level 0 products. The cL0 products are the basis for level 0-1b and level 1b-2 processing whenever highest precision is required. It was therefore of paramount importance to develop a cL0 data archive for the entire in-orbit mission lifetime being as complete as possible and containing quality controlled measurement data

The SCIAMACHY Consolidated Level 0 Master Archive

The delivery of SCIAMACHY level 0 data from ESA to DLR is one of the instrument provider’s specific data interfaces in the Payload Data Segment. For consolidated level 0 (cL0) data, this interface has been technically implemented via a transfer between the D-PAC and DLR. This transfer generates a complete master measurement data set of SCIAMACHY cL0 products. In this presentation we provide the current status of the cL0 master archive, covering completely processed years 2002-2007

SCIAMACHY Operations History and the New Level 1b Product - an Approach for Long-term Data Preservation

SCIAMACHY on ENVISAT has acquired, over a period of 10 years, a wealth of high quality measurement data. After the end of the SCIAMACHY/ENVISAT mission it has become a paramount goal to ensure long-term availability of this dataset together with auxiliary information such as instrument operations and configuration know-how. We will store essential operations and instrument information in the new level 1b product, which will be developed in the framework of the SQWG phase F. We report on the overall concept of operations and instrument information in the SCIAMACHY level 1b product and on the current status of its implementation

Per(2-thienyl)pyridines: Synthesis and Properties

Starting from an easily available pyridinol derivative, a route to penta(2-thienyl)pyridine and related symmetrical compounds is reported. Key reactions are activation of the pyridine core and metal-catalyzed couplings proving the efficacy of these methods even in sterically highly encumbered systems. UV/vis and fluorescence spectra as well as first cyclovoltametric measurements of the synthesized novel thiophene–pyridine conjugates are reported

User interface of the EnMap Ground Segment

The EnMAP Ground Segment will be implemented and operated by the German Aerospace Center (DLR). The Applied Remote Sensing Cluster (DFD) at DLR is responsible for the establishment of a user interface for the future German hyperspectral satellite mission EnMAP (Environmental Mapping and Analysis Program). This paper provides first issues on design and functionality of the user interface. The user interface consists of two hierarchically structured online portals. The EnMAP portal is the central entry point for all users interested to learn about the EnMAP mission, its objectives, status, and results. The EnMAP Data Access Portal (EDAP) links to a set of functions for registered users that will support the international EnMAP user community. The operational services offered through the EnMAP portal will be complemented by a service team, EnMAP Application Support, offering expert advice on the exploitation of EnMAP data

Triggers and Treatment of Anaphylaxis An Analysis of 4000 Cases From Germany, Austria and Switzerland

Background: Anaphylaxis is the most severe manifestation of a mast cell-dependent immediate reaction and may be fatal. According to data from the Berlin region, its incidence is 2-3 cases per 100 000 persons per year. Methods: We evaluated data from the anaphylaxis registry of the German-speaking countries for 2006-2013 and data from the protocols of the ADAC air rescue service for 2010-2011 to study the triggers, clinical manifestations, and treatment of anaphylaxis. Results: The registry contained data on 4141 patients, and the ADAC air rescue protocols concerned 1123 patients. In the registry, the most common triggers for anaphylaxis were insect venom (n = 2074; 50.1%), foods (n = 1039; 25.1%), and drugs (n = 627; 15.1%). Within these groups, the most common triggers were wasp (n = 1460) and bee stings (n = 412), legumes (n = 241), animal proteins (n = 225), and analgesic drugs (n = 277). Food anaphylaxis was most frequently induced by peanuts, cow milk, and hen's egg in children and by wheat and shellfish in adults. An analysis of the medical emergency cases revealed that epinephrine was given for grade 3 or 4 anaphylaxis to 14.5% and 43.9% (respectively) of the patients in the anaphylaxis registry and to 19% and 78% of the patients in the air rescue protocols. Conclusion: Wasp and bee venom, legumes, animal proteins, and analgesic drugs were the commonest triggers of anaphylaxis. Their relative frequency was age-dependent. Epinephrine was given too rarely, as it is recommended in the guidelines for all cases of grade 2 and above